Radiosensitization of biologically active DNA in cellular extracts by oxygen. Evidence that the presence of SH compounds is not required
article
The radiosensitization by oxygen of biologically active bacteriophage DNA in bacterial extracts was studied. The oxygen effect in such a system appeared not to be due or only to a minor extent to the presence of endogenous sulphydryl compounds. The components in a cell extract which enable oxygen and other sensitizers to sensitize DNA could not be destroyed by extremely high doses of γ radiation. Chemicals/CAS: DNA, 9007-49-2; oxygen, 7782-44-7; thiol derivative, 13940-21-1; Azo Compounds; Cobalt Radioisotopes; Cyclic N-Oxides; Cysteamine, 60-23-1; DNA, Circular; DNA, Viral; Ethylmaleimide, 128-53-0; Oxygen, 7782-44-7; Radiation-Sensitizing Agents; Sulfhydryl Compounds
Topics
Bacteriophage dnaDNAOxygenRadioisotopeThiol derivativeGamma radiationIn vitro studyMethodologyMicroorganismRadiosensitivityRadiosensitizationTheoretical studyAzo CompoundsCobalt RadioisotopesColiphagesCyclic N-OxidesCysteamineDNA VirusesDNA, CircularDNA, ViralDose-Response Relationship, RadiationEscherichia coliEthylmaleimideGamma RaysMutationOxygenPseudomonasRadiation EffectsRadiation-Sensitizing AgentsSulfhydryl Compounds
TNO Identifier
227740
ISSN
09553002
Source
International Journal of Radiation Biology, 26(6), pp. 547-555.
Pages
547-555
Files
To receive the publication files, please send an e-mail request to TNO Repository.