Toxicologic studies of iocetamic acid in rats and dogs
article
A new oral cholecystographic medium called iocetamicacid was submitted to a toxicologic study in rats and dogs. Dosages, which were equivalent to 200 and 1000 mg of the compound per kilogram of body weight per day and were 5 times and 25 times the human routine dose, were administered daily for 3 weeks in order to establish whether the substance exerted an untoward influence on vital organs. In the male rats the thyroid was activated by both doses, but no thyroid activation was demonstrable in dogs. There were no indications of damage of the cells of the liver or kidney. The study showed that iocetamic acid had no special affinity for the kidneys. With the exception of the increased thyroid activity in male rats, no changes were found which could be ascribed to the administration of iocetamic acid. © 1969.
Chemicals/CAS: iodine, 7553-56-2; Butyrates; Contrast Media; Iodine, 7553-56-2
Chemicals/CAS: iodine, 7553-56-2; Butyrates; Contrast Media; Iodine, 7553-56-2
Topics
TNO Identifier
227110
ISSN
0041008X
Source
Toxicology and Applied Pharmacology, 14(2), pp. 242-248.
Pages
242-248
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