Growth inhibition of bacteria by tributylgermanium acetate and its reversal by blood constituents

article
Kaars Sijpesteijn, A.
Growth inhibition of Mycobacterium phlei by tributylgermanium acetate can be reversed by addition of large amounts of blood or blood serum to the nutrient medium; the blood erythrocyte fraction is inactive. On the other hand growth inhibition of the lactic acid bacteria Streptococcus lactis and Leuconostoc mesenteroides can be counteracted by traces of blood or its crythrocyte fraction, by hemin and by catalase. Blood serum even in large amounts is ineffective. Whereas tributylgermanium acetate is highly active against most lactic acid bacteria studied, the antagonistic action of blood or hemin is found only with the species named. The possible mechanism of this antagonism is discussed. © 1968 Swets & Zeitlinger. Chemicals/CAS: catalase, 9001-05-2; germanium, 7440-56-4; heme, 14875-96-8; peroxidase, 9003-99-0; Antifungal Agents; Catalase, EC 1.11.1.6; Germanium, 7440-56-4; Heme, 14875-96-8; Peroxidases, EC 1.11.1.
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Antifungal agentCatalaseGermaniumHemePeroxidaseBloodErythrocyteGrowth, development and agingLeuconostocMetabolismMycobacteriumStreptococcusAntifungal AgentsBloodCatalaseErythrocytesGermaniumHemeLeuconostocMycobacteriumPeroxidasesStreptococcus
TNO Identifier
227075
Repository link
https://resolver.tno.nl/uuid:c641b9be-15f9-45a4-b733-e8957cb1076f
ISSN
00036072
Source
Antonie van Leeuwenhoek, 34(1), pp. 85-92.
Pages
85-92
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