Effect of radioprotective sulphydryl compounds on the oxygen tension in the spleen of mice
article
In a previous paper the mechanism of the radioprotective action of the biologically active amines histamine, epinephrine, tryptamine and β-phenylethylamine was investigated. In studying the effect of these compounds on the oxygen tension in the spleen and bone marrow of unanæsthetized mice strong evidence was obtained that a relation exists between the percentage protection against a lethal dose of X-rays afforded by these compounds and the degree of hypoxia caused in the blood-forming organs. Furthermore, it was shown2 that cyanide also causes hypoxia in the spleen as a consequence of vasoconstriction and that this effect may well explain its protective action in mice. © 1961 Nature Publishing Group.
TNO Identifier
226757
ISSN
00280836
Source
Nature, 189(4764), pp. 588-589.
Pages
588-589
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