Extractant selection strategy for solvent-impregnated resins in fermentations

article





Berg, C. van den

Roelands, C.P.M.

Bussmann, P.J.T.

Goetheer, E.L.V.

Verdoes, D.

Wielen, L. van der
The application of extractants in whole-cell biocatalysis can have a positive impact on industrial fermentations, in terms of productivity, total amount of product produced, and cell growth. When a product is continuously removed from the microorganism surroundings, product inhibition will be diminished. The strategy is exemplified using phenol as the product and the extractant is selected for solvent-impregnated resins, which can prevent emulsification problems that are commonly encountered in in situ extractive recovery of fermentation products. A systematic approach for selection of superior extractants in whole-cell biocatalysis is discussed in this paper. Three criteria are taken into account, namely, extractant toxicity (log P o/w values), product selectivity, and extractant regeneration.
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ExtractantsFermentation productsIn-situIndustrial fermentationsProduct inhibitionsProduct selectivitiesSolvent-impregnated resinsWhole-cell biocatalysisBiochemical engineeringCell growthEmulsificationGrowth kineticsPhenolic resinsPhenolsResinsImpregnationChemistry
TNO Identifier
241285
Repository link
https://resolver.tno.nl/uuid:d53ac9e8-97fb-4f7e-9ee5-06dc05e134a1
ISSN
08885885
Source
Industrial and Engineering Chemistry Research, 47(24), pp. 10071-10075.
Pages
10071-10075
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