Strongly increased levels of fibrinogen elastase degradation products in patients with ischemic stroke

article







Lau, L.M.L. de

Cheung, E.Y.L.

Kluft, C.

Leebeek, F.W.G.

Meijer, P.

Laterveer, R.

Dippel, D.W.J.

Maat, M.P.M.de
Ischemic stroke is associated with leucocyte activation. Activated leucocytes release elastase, an enzyme that can degrade fibrinogen. Fibrinogen elastase degradation products (FgEDP) may serve as a specific marker of elastase proteolytic activity. In a case-control study of 111 ischemic stroke patients and 119 controls, significantly higher FgEDP levels were observed in cases than in controls, both in the acute phase and in the convalescent phase. Results were only slightly affected by adjustment for cardiovascular risk factors, C-reactive protein and fibrinogen. Our findings suggest that FgEDP might be involved in the pathogenesis of stroke. © 2008 The Authors.
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Biomedical ResearchElastaseEpidemiologyFibrinogen degradation productsLeucocyte activationStrokeC reactive proteinelastasefibrinogenadultarticlecardiovascular riskcerebrovascular accidentcontrolled studyconvalescencedisease coursefemalefibrinogen blood levelhumanmajor clinical studymalepriority journalprotein degradationstroke patientAdultAgedBiological MarkersC-Reactive ProteinCase-Control StudiesFemaleFibrin Fibrinogen Degradation ProductsFibrinogenHumansIschemic Attack, TransientLymphocyte ActivationMaleMiddle AgedOdds RatioPancreatic ElastaseRiskStroke
TNO Identifier
241226
Repository link
https://resolver.tno.nl/uuid:9f82f039-53a1-4bd2-a2ca-5749d8ef378f
ISSN
00071048
Source
British Journal of Haematology, 143(5), pp. 734-737.
Pages
734-737
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