Endothelium specific matrilysin (MMP-7) expression in human cancers
article
Over-expression of matrilysin (MMP-7) is predominantly associated with epithelial (pre)malignant cells. In the present study MMP-7 expression is also found in endothelial cells in various human cancer types. Endothelial MMP-7 was associated with CD34 and/or CD105 expression. These immunohistochemical data were confirmed by RT-PCR on VEGF-stimulated endothelial cells. In addition, MMP-7 was also identified in sprouting endothelial cells in vitro. The potential clinical relevance of endothelial MMP-7 was assessed for cervical cancer patients by evaluating the association with overall survival. In contrast to MMP-7 in malignant epithelial cells, MMP-7 expression in endothelial cells showed a significant association with poor survival (LR 5.12, P = 0.02, n = 30). Our data suggest that MMP-7 is involved in tumor angiogenesis, thereby contributing to malignant growth and hence associated with decreased survival. © 2007 International Society of Matrix Biology.
Topics
Physiological SciencesAngiogenesisBreastCarcinomaCervixColonMatrix metalloproteinaseProstateStomachCD34 antigenendoglinmatrilysinvasculotropinadultagedangiogenesisantigen expressionarticlecancer cellcancer growthcancer patientcancer survivalendothelium cellfemalehumanhuman cellhuman tissueimmunohistochemistryin vitro studymajor clinical studymalignant neoplastic diseasepriority journalprotein expressionreverse transcription polymerase chain reactiontumor vascularizationuterine cervix cancerCarcinomaCell Line, TumorEndotheliumFemaleGene Expression Regulation, EnzymologicGene Expression Regulation, NeoplasticHumansMatrix Metalloproteinase 7Neoplasm InvasivenessNeovascularization, PathologicSpheroids, CellularTime FactorsTissue DistributionUmbilical VeinsUterine Cervical Neoplasms
TNO Identifier
240728
ISSN
0945053X
Source
Matrix Biology, 27(3), pp. 267-271.
Pages
267-271
Files
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