Comparison of a transdermal contraceptive patch vs. oral contraceptives on hemostasis variables

article



Kluft, C.

Meijer, P.

LaGuardia, K.D.

Fisher, A.C.
Purpose: The aim of this study was to compare effects of the transdermal contraceptive patch, a desogestrel/ethinyl estradiol (EE)-containing, monophasic combination oral contraceptive (COC) and a levonorgestrel/EE-containing, triphasic COC on hemostasis variables. Study Design: This was a randomized, open-label study of 104 young women who received six cycles of treatment. Blood was collected at baseline and on treatment; changes by Day 20/Cycle 6 in baseline hemostasis markers [prothrombin fragment 1+2 (F 1+2), plasmin-plasmin inhibitor complex (PAP) and fibrin degradation products (d-dimer)] were assessed. Results: All contraceptives induced similar increases in F 1+2 and d-dimer. Patch-induced PAP increases were less than with the monophasic and similar to the triphasic COC. Decreases in protein S and increases in sex hormone-binding globulin were greater with the patch than with either COC. Patch-induced increases in activated protein C resistance were greater than with the triphasic and similar to the monophasic COC. Conclusion: These contraceptives appeared to accelerate baseline procoagulation processes to a similar extent and to change coagulation potency variables differently. © 2008 Elsevier Inc. All rights reserved.
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FibrinMonophasicProcoagulationProthrombinTriphasiccontraceptive agentD dimerdesogestrel plus ethinylestradiolethinylestradiol plus levonorgestrelfibrin degradation productoral contraceptive agentplasmin inhibitorprotein Sprothrombinsex hormone binding globulinactivated protein C resistanceadultarticleblood clottingblood samplingclinical trialcontrolled clinical trialcontrolled studydrug mechanismfemalehemostasishumanintermethod comparisonmajor clinical studyopen studypatch testrandomized controlled trialAdministration, CutaneousAdministration, OralAdolescentAdultAntifibrinolytic AgentsBiological MarkersBlood CoagulationBlood Coagulation FactorsContraceptives, Oral, CombinedDesogestrelEthinyl EstradiolFemaleFibrin Fibrinogen Degradation ProductsHomeostasisHumansLevonorgestrelMiddle AgedPeptide FragmentsPlasminProspective StudiesProtein PrecursorsProthrombin
TNO Identifier
240619
Repository link
https://resolver.tno.nl/uuid:c8bad12b-4651-4ed1-b304-fdb7bf7bfbf6
ISSN
00107824
Source
Contraception, 77(2), pp. 77-83.
Pages
77-83
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