From dermal exposure to internal dose
article
Exposure scenarios form an essential basis for chemical risk assessment reports under the new EU chemicals regulation REACH (Registration, Evaluation, Authorisation and restriction of Chemicals). In case the dermal route of exposure is predominant, information on both exposure and dermal bioavailability is necessary for a proper risk assessment. Various methodologies exist to measure dermal exposure, providing quantitative or semiquantitative information. Although these studies may provide very specific and relevant information, it should be realized that case by case in-depth exposure assessment would be a very expensive process. Dermal bioavailability data are most often obtained from in vitro studies or animal experiments. For the design of studies, which generate data relevant for chemical risk assessment, detailed information on the exposure conditions is crucial (skin surface exposed, exposure duration, dose and physical state of the chemical). Results from non-testing methods for skin absorption, such as (Q)SARs, have been used only to a very limited extent for regulatory purposes. Suggestions are made in order to extend the use these methods to dermal risk assessment of chemical substances, thereby improving the practicability of REACH. © 2007 Nature Publishing Group All rights reserved.
Topics
Food and Chemical Risk Analysis(Q)SARBioavailabilityDermal exposureInternal doseModellingSkin absorptionalgorithmbioavailabilitycontaminationdose responsehumanlawnonhumanpopulation exposurereviewrisk assessmentskin absorptionskin permeabilityskin toxicityAnimalsBiological AvailabilityChemical IndustryEnvironmental ExposureEnvironmental MonitoringEuropean UnionHumansModels, AnimalModels, BiologicalModels, ChemicalPermeabilityRisk AssessmentSkin AbsorptionAnimalia
TNO Identifier
240416
ISSN
15590631
Source
Journal of Exposure Science and Environmental Epidemiology, 17(SUPPL. 1)
Files
To receive the publication files, please send an e-mail request to TNO Repository.