Volume overload cleanup: an approach for on-line SPE-GC, GPC-GC, and GPC-SPE-GC

article


Kerkdijk, H.

Mol, H.G.J.

Nagel, B. van der
A new concept for cleanup, based on volume overloading of the cleanup column, has been developed for on-line coupling of gel permeation chromatography (GPC), solid-phase extraction (SPE), or both, to gas chromatography (GC). The principle is outlined and the applicability demonstrated by the determination of pesticide residues in food matrixes using integrated and automated cleanup-GC-MS. Compared to conventional approaches for on-line cleanup-GC, the new technique involves introduction of much smaller volumes (e.g., 2-20 μL) into the GC without sacrificing method LODs. The much smaller injection volumes involved greatly simplify on-line coupling, improve robustness, and increase attractiveness for implementation in routine laboratories.
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Analytical researchGas chromatographyGel permeation chromatographyPesticidesCleanup columnFood matrixesSolid phase extraction (SPE)Volume overload cleanupExtractionChemical analysisLaboratory testMass spectrometryOnline analysisChlorophyllGel chromatographyFish oilsFood analysisPesticide residuesSensitivity and specificity
TNO Identifier
240278
Repository link
https://resolver.tno.nl/uuid:40abc93f-f434-4209-a631-f0bfb4b24b0e
ISSN
0003-2700
Source
Analytical Chemistry, 79(21), pp. 7975-7983.
Pages
7975-7983
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