Dynamics in prophage content of invasive and noninvasive M1 and M28 Streptococcus pyogenes isolates in the Netherlands from 1959 to 1996
article
Invasive group A streptococcal (GAS) disease reemerged in The Netherlands in the late 1980s. To seek an explanation for this resurgence, the genetic compositions of 22 M1 and 19 M28 GAS strains isolated in The Netherlands between 1960s and the mid-1990s were analyzed by using a mixed-genome DNA microarray. During this four-decade period, M1 and especially M28 strains acquired prophages on at least eight occasions. All prophages carried a superantigen (speA2, speC, speK) or a streptodornase (sdaD2, sdn), both associated with invasive GAS disease. Invasive and noninvasive GAS strains did not differ in prophage acquisition, suggesting that there was an overall increase in the pathogenicity of M1 and M28 strains over the last four decades rather than emergence of hypervirulent subclones. The increased overall pathogenic potential may have contributed to the reemergence of invasive GAS disease in The Netherlands. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
Topics
Biotechnologyprotein sdaD2protein sdnspeA2 antigenspeC antigenspeK antigenstreptodornasesuperantigenunclassified drugarticlebacterial genomebacterial strainbacterial virulencebacterium isolatecontrolled studyDNA microarrayNetherlandsnonhumannucleotide sequencepriority journalprophageStreptococcus group AStreptococcus infectionStreptococcus pyogenesAntigens, BacterialBacterial Outer Membrane ProteinsCarrier ProteinsDeoxyribonuclease IHumansNetherlandsOligonucleotide Array Sequence AnalysisPolymerase Chain ReactionProphagesStreptococcal InfectionsStreptococcus PhagesStreptococcus pyogenesSuperantigensVirulenceVirulence Factors
TNO Identifier
240041
ISSN
00199567
Source
Infection and Immunity, 75(7), pp. 3673-3679.
Pages
3673-3679
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