Alcohol consumption, cigarette smoking, and endometrial cancer risk: Results from the Netherlands Cohort Study
article
Objective: To examine the association between alcohol consumption, cigarette smoking, and endometrial cancer. Methods: In 1986, the Netherlands Cohort Study was initiated. A self-administered questionnaire on dietary habits and other cancer risk factors was completed by 62,573 women. Follow-up for cancer was established by record linkage to the Netherlands Cancer Registry. Results: After 11.3-years of follow-up, 280 incident endometrial cancer cases were available for analyses. In multivariate analysis, the rate ratio (RR) for alcohol users versus non-users was 1.06 (95% Confidence Interval (95% CI)= 0.78-1.43). There were neither dose-dependent trends nor associations with different types of beverages. The RR for former and current smokers versus never-smokers was 0.83 (95% CI = 0.58-1.20) and 0.59 (95% CI = 0.40-0.88), respectively. These estimates did not change significantly when body mass index (BMI) and age at menopause were added to the models. Conclusions: There is no association between alcohol consumption and endometrial cancer. Current smoking is associated with a reduced risk of endometrial cancer. This association is neither mediated by BMI nor by age at menopause. © 2007 Springer Science+Business Media B.V.
Topics
Food and Chemical Risk Analysis
Alcohol drinking
Cohort studies
Endometrial neoplasms
Netherlands
Smoking
Alcohol
Adult
Alcohol consumption
Beverage
Body mass
Cancer incidence
Cancer registry
Cancer risk
Cigarette smoking
Cohort analysis
Confidence interval
Controlled study
Diet
Disease association
Endometrium cancer
Follow up
Major clinical study
Multivariate analysis
Netherlands
Priority journal
Questionnaire
Risk assessment
Risk factor
Aged
Alcohol Drinking
Body Mass Index
Cohort Studies
Contraceptives, Oral
Endometrial Neoplasms
Female
Humans
Menopause
Middle Aged
Risk Factors
Smoking
TNO Identifier
239994
DOI
https://dx.doi.org/10.1007/s10552-007-0127-x
ISSN
09575243
Source
Cancer Causes and Control, 18(5), pp. 551-560.
Pages
551-560
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