A guide to murine coagulation factor structure, function, assays, and genetic alterations
article
Murine blood coagulation factors and function are quite similar to those of humans. Because of this similarity and the adaptability of mice to genetic manipulation, murine coagulation factors and inhibitors have been extensively studied. These studies have provided significant insights into human hemostasis. They have also provided useful experimental models for evaluation of the pathophysiology and treatment of thrombosis. This review contains recommendations for obtaining, processing and assaying mouse blood hemostatic components, and it summarizes the extensive literature on murine coagulation factor structure and function, assays and genetic alteration. It is intended to be a convenient reference source for investigators of hemostasis and thrombosis. © 2007 International Society on Thrombosis and Haemostasis. Chemicals / CAS: antithrombin, 9000-94-6; blood clotting factor 10, 9001-29-0; blood clotting factor 13, 9013-56-3; blood clotting factor 5, 9001-24-5, 9013-23-4; blood clotting factor 7, 9001-25-6; blood clotting factor 8, 9001-27-8; blood clotting factor 9, 9001-28-9; fibrinogen, 9001-32-5; heparin cofactor II, 81604-65-1; protein C, 60202-16-6; prothrombin, 9001-26-7; thrombin, 9002-04-4; thrombomodulin, 112049-68-0; tissue factor pathway inhibitor, 116638-34-7; von Willebrand factor, 109319-16-6; Fibrinogen, 9001-32-5
Topics
AntithrombinBlood clotting factorBlood clotting factor 10Blood clotting factor 13Blood clotting factor 5Blood clotting factor 7Blood clotting factor 8Blood clotting factor 9D dimerEndothelial protein C receptorFibrinogenHeparin cofactor IIProtein CProtein SThrombinThrombomodulinTissue factor pathway inhibitorVon Willebrand factorAtherosclerosisEnzyme linked immunosorbent assayGene mutationImmunoelectrophoresisMetastasisNonhumanPartial thromboplastin timePhenotypeProtein functionProtein structureThrombocyte aggregationTumor vascularizationWestern blottingWound healingAnimalsBlood CoagulationDisease Models, AnimalFibrinogenHemostasisHumansMiceModels, BiologicalModels, GeneticPartial Thromboplastin TimeProthrombin TimeThrombosis
TNO Identifier
239925
ISSN
15387933
Source
Journal of Thrombosis and Haemostasis, 5(4), pp. 670-679.
Pages
670-679
Files
To receive the publication files, please send an e-mail request to TNO Repository.