Interleukin 10: A new risk marker for the development of restenosis after percutaneous coronary intervention

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Monraats, P.S.

Kurreeman, F.A.S.

Pons, D.

Sewgobind, V.D.K.D.

Vries, F.R. de

Zwinderman, A.H.

Maat, M.P.M. de

Doevendans, P.A.

Winter, R.J. de

Tio, R.A.

Waltenberger, J.

Huizinga, T.W.J.

Eefting, D.

Quax, P.H.A.

Frants, R.R.

Laarse, A. van der

Wall, E.E. van der

Jukema, J.W.
Genetic factors appear to be important in the process of restenosis after percutaneous coronary intervention (PCI), as well as in inflammation, a pivotal factor in restenosis. An important mediator in the inflammatory response is interleukin (IL)-10. Our aim was to study whether genetic variants in IL-10 predispose to the risk of restenosis. The GENetic DEterminants of Restenosis (GENDER) study included 3104 patients treated with successful PCI. Target vessel revascularization (TVR) was chosen as primary end point. Genotyping of the -2849G/A, -1082G/A, -592C/A and +4259A/G polymorphisms of the IL-10 gene was performed by MassArray platform. After adjusting for clinical variables, three polymorphisms significantly increased the risk of restenosis (-2849AA: relative risk (RR), 1.7, 95% confidence interval (CI), 1.2-2.5; -1082AA: RR, 1.4, 95% CI, 1.1-1.8 and +4259GG: RR, 2.0, 95% CI, 1.4-2.8). To further exclude possible involvement of neighboring genes due to LD in the IL-10 locus, additional polymorphisms were genotyped. The results reveal that association of the IL-10 gene with restenosis is independent of flanking genes. Our findings demonstrate that IL-10 is associated with restenosis and therefore support the hypothesis that anti-inflammatory genes also may be involved in developing restenosis. Furthermore, they may provide a new targeting gene for drug-eluting stents.
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Biomedical ResearchAlanineClopidogrelCysteineGlycineInterleukin 10TiclopidineAdultAgedCardiovascular riskConfidence intervalControlled studyCoronary artery bypass graftDisease markerDNA flanking regionDNA microarrayDrug eluting stentFemaleGene linkage disequilibriumGene locusGenetic associationGenetic polymorphismGenetic predispositionGenetic riskGenetic variabilityGenotypeHeart infarctionHumanHypothesisIn-stent restenosisMajor clinical studyMalePathogenesisPercutaneous coronary interventionPriority journalRisk factor3' Untranslated RegionsAgedAngioplasty, Transluminal, Percutaneous CoronaryCoronary RestenosisFemaleGenetic Predisposition to DiseaseGenotypeHumansInflammationInterleukin-10MaleMiddle AgedPolymorphism, GeneticPromoter Regions (Genetics)Prospective StudiesRisk FactorsTreatment Outcome
TNO Identifier
239819
Repository link
https://resolver.tno.nl/uuid:2cfa5e68-4355-4e04-9f69-c0b0c996b0a8
ISSN
14664879
Source
Genes and Immunity, 8(1), pp. 44-50.
Pages
44-50
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