Mediators of apoptosis Fas and FasL predict disability progression in multiple sclerosis over a period of 10 years
article
TNF-α, IL-12p35, IL-12p40, IL-4, IL-10, TGF-β1, CCR3, CXCR3, CCR5, Fas and FasL mRNA levels in PBMC of 25 multiple sclerosis (MS) patients were quantified at baseline by real-time PCR according to a post-hoc study design. The baseline values of the different markers were analysed with respect to their correlation with the increase in disability over a period of 10 years. High levels of Fas mRNA were associated with a favourable disease course in relapsing-remitting (RR) MS (R2 = 0.74, P = 0.0001, n = 13), as measured by the Expanded Disability Status Scale (EDSS); high levels of FasL mRNA were associated with relatively mild disease progression (R2 = 0.86, P = 0.0001, n = 12) in secondary progressive (SP) MS. These findings suggest that Fas-mediated apoptosis plays a major role in the mechanism underlying long-term disease progression in MS. © 2006 SAGE Publications. Chemicals / CAS: osteopontin, 106441-73-0; Antibodies, Monoclonal; Antigens, CD95; Biological Markers; Chemokines; Cytokines; Fas Ligand Protein; RNA, Messenger
Topics
Biomedical ResearchApoptosisChemokinesCytokinesEDSSFasMSchemokine receptor CCR3chemokine receptor CCR5chemokine receptor CXCR3Fas antigenFAS ligandinterleukin 10interleukin 12p35interleukin 12p40interleukin 4messenger RNAOKT 4osteopontintransforming growth factor beta1tumor necrosis factor alphaadultapoptosisarticleclinical articlecontrolled studycorrelation analysisdisabilitydisease associationdisease courseExpanded Disability Status Scalefemalehumanhuman cellmalemultiple sclerosispathophysiologyperipheral blood mononuclear cellpost hoc analysispredictionquantitative analysisreal time polymerase chain reactionrelapseremissionAdultAntibodies, MonoclonalAntigens, CD95ApoptosisBiological MarkersChemokinesCytokinesDisability EvaluationFas Ligand ProteinFemaleFollow-Up StudiesHumansMaleMiddle AgedMultiple Sclerosis, Chronic ProgressiveMultiple Sclerosis, Relapsing-RemittingPredictive Value of TestsRNA, Messenger
TNO Identifier
239675
ISSN
13524585
Source
Multiple Sclerosis, 12(6), pp. 704-709.
Pages
704-709
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