Modulatory effects of quercetin on proliferation and differentiation of the human colorectal cell line Caco-2
article
The effect of the dietary flavonoid quercetin was investigated on proliferation and differentiation of the human colon cancer cell line Caco-2. Confluent Caco-2 monolayers exposed to quercetin showed a biphasic effect on cell proliferation and a decrease in cell differentiation (0.001<P<0.05). During differentiation Caco-2 cells formed 5 phase II metabolites, of which the amount of 4′-O-methyl-quercetin-3′-O-glucuronide correlated with the differentiation grade (r=0.99, P<0.003). The increment of cell proliferation at low quercetin concentrations and the decrease in cell differentiation are effects opposite to what would be expected for a functional food ingredient with anti-carcinogenic potential. © 2005 Elsevier Ireland Ltd. All rights reserved.
Topics
Toxicology and Applied PharmacologyCaco-2Colorectal cancerDifferentiationMetabolismProliferationQuercetin3' o methylquercetin 4' o glucuronide3' o methylquercetin 7 o sulfate4' o methylquercetin 3' o glucuronide4' o methylquercetin 7 o glucuronideIsorhamnetinQuercetinQuercetin derivativeUnclassified drugCell differentiationCell proliferationCell strain CACO 2Controlled studyHumanHuman cellPriority journalStatistical significanceAnticarcinogenic AgentsCaco-2 CellsCell DifferentiationCell ProliferationColorectal NeoplasmsDrug StabilityHumansQuercetin
TNO Identifier
239375
ISSN
03043835
Source
Cancer Letters, 238(2), pp. 248-259.
Pages
248-259
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