General aspects of immunotoxicology including validation issues

article
Frieke Kuper, C.
Histologic examination of lymphoid organs has revealed immunotoxic effects of a broad range of substances. The thymus has proven especially sensitive. The relative lack of sensitivity of mucosa-associated lymphoid cells and tissues may be due to shortcomings in the way they are examined. Validation of ways to examine mucosal lymphoid tissues and cells and development of histopathological tools to flag a compound as a potential inducer of autoimmune disease or allergy are challenges for the future. © 2006 Elsevier GmbH. All rights reserved.
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Toxicology and Applied PharmacologyImmunopathologyOrgan samplingValidationAllergyAutoimmune diseaseHistologyHistopathologyHumanImmunotoxicityImmunotoxicologyLymphoid cellLymphoid organLymphoid tissueSensitivity and specificityThymusToxicologyValidation studyAnimalsImmune SystemImmunosuppressive AgentsLymphoid TissueReproducibility of ResultsToxicity TestsXenobiotics
TNO Identifier
239364
Repository link
https://resolver.tno.nl/uuid:07b309ea-0da6-4715-b2f3-00bc27a0cd9d
ISSN
09402993
Source
Experimental and Toxicologic Pathology, 57(5-6), pp. 363-366.
Pages
363-366
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