Lost in translation? Role of metabolomics in solving translational problems in drug discovery and development

article



Greef, J. van der

Adourian, A.

Muntendam, P.

McBurney, R.N.
Too few drug discovery projects generate a marketed drug product, often because preclinical studies fail to predict the clinical experience with a drug candidate. Improving the success of preclinical-to-clinical translation is of paramount importance in optimizing the pharmaceutical value chain. Here, we advance the case for a molecular systems approach to crossing the preclinical-to-clinical translational chasm and for metabolomic analysis of readily accessible bodyfluids as a key technology in translational activities. © 2006.
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Analytical researchBiological markerDrug metaboliteNew drugBioinformaticsBody fluidData baseDecision makingDrug determinationDrug efficacyDrug marketingDrug researchDrug safetyHumanMedical technologyMetabolomicsMultiple sclerosisNon insulin dependent diabetes mellitusNonhumanOsteoarthritisPhenotypePostmarketing surveillanceProteomicsReviewSerologyStructure activity relation
TNO Identifier
239279
Repository link
https://resolver.tno.nl/uuid:5850bbf0-cb1e-414b-ab1d-c0d54647895b
ISSN
17406749
Source
Drug Discovery Today: Technologies, 3(2), pp. 205-211.
Pages
205-211
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