Myricetin stimulates the absorption of the pro-carcinogen PhIP
article
The effect of the flavonoid myricetin on the transport of the pro-carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through differentiated Caco-2 monolayers, a model for the intestinal epithelium, is described. Myricetin causes an increase of the transport of PhIP from the apical to the basolateral compartment. This effect was observed at physiologically relevant concentrations of PhIP and myricetin. Cyclosporin A (MRP2 inhibitor) but not PSC833 (P-gp inhibitor) showed a similar effect on PhIP transport. The results indicate that myricetin induces an increased basolateral uptake of the pro-carcinogen PhIP, in part through inhibition of the MRP2 mediated excretion of PhIP from the intestinal cells back to the lumen. © 2005 Elsevier Ireland Ltd. All rights reserved.
Topics
Biomedical ResearchABC transporterApparent permeabilityCaco-2MyricetinPhIP2 amino 1 methyl 6 phenylimidazo[4,5 b]pyridineCarcinogenCyclosporin AGlycoprotein P inhibitorMultidrug resistance protein 2MyricetinValspodarAbsorptionCell differentiationCell strain CACO 2Cell transportConcentration (parameters)ExcretionHumanHuman cellIntestine epithelium cellPriority journalStimulationAbsorptionATP-Binding Cassette TransportersCaco-2 CellsCarcinogensFlavonoidsHumansImidazolesMembrane Transport ProteinsMultidrug Resistance-Associated ProteinsPermeability
TNO Identifier
239087
ISSN
03043835
Source
Cancer Letters, 231(1), pp. 36-42.
Pages
36-42
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