Systems biology, connectivity and the future of medicine
article
The concept of systems-based strategies in medicine is emerging, with systems pathology guiding an understanding of the multidimensional aspects of disease system fingerprints and systems pharmacology providing insight into dynamic system responses upon (multiple) drug perturbations. Knowledge of the changes of system characteristics during disease progression creates a framework for the design of novel combinatorial treatment strategies. Such a systems-based, combinatorial-therapies approach readdresses the value of the synergistic actions of components of treatments based on natural products and highlights new methodology to study multidimensional intervention via reversed-pharmacology. © IEEE, 2005.
Topics
Analytical researchDisease progressionDisease system fingerprintsDiseasesDrug perturbationsDrugsMedicinePatient treatmentReversed-pharmacologySystems biologySystems pathologySystems pharmacologySystems-based combinatorial-therapies approachBiologyDiseasesDrug therapyPathologyPharmacokineticsDisease system fingerprintsPharmacologySystems biologyDrug productsAmlodipine plus atorvastatinBerberineBiological markerFluticasone propionate plus salmeterolGinseng extractGlibenclamide plus metforminAsthmaBioinformaticsBiostatisticsCardiovascular diseaseClinical protocolDisease courseDrug designDrug industryDrug researchHumanHypercholesterolemiaIn vivo studyMedicineMetabolic syndrome XMethodologyMolecular biologyNon insulin dependent diabetes mellitusNonhumanQuality controlQuality of lifeCell PhysiologyDrug DesignModels, BiologicalPharmaceutical PreparationsPharmacologyPharmacology, ClinicalSystems BiologyPanax ginseng
TNO Identifier
238849
ISSN
17412471
Source
IEE Proceedings Systems Biology, 152(4), pp. 174-178.
Pages
174-178
Files
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