Meat and fish consumption, APC gene mutations and hMLH1 expression in colon and rectal cancer: A prospective cohort study (The Netherlands)
article
Objective: The aim of this study was to investigate the associations between meat and fish consumption and APC mutation status and hMLH1 expression in colon and rectal cancer. Methods: The associations were investigated in the Netherlands Cohort Study, and included 434 colon and 154 rectal cancer patients on whom case-cohort analyses (subcohort n = 2948) were performed. Results: Total meat consumption was not associated with the endpoints studied. Meat product (i.e. processed meat) consumption showed a positive association with colon tumours harbouring a truncating APC mutation, whereas beef consumption was associated with an increased risk of colon tumours without a truncating APC mutation (incidence rate ratio (RR) highest versus lowest quartile of intake 1.61, 95% confidence interval (CI) 0.96-2.71, p-trend = 0.04 and 1.58, 95% CI 1.10-2.25, p-trend = 0.01, respectively). Consumption of other meat (horsemeat, lamb, mutton, frankfurters and deep-fried meat rolls) was associated with an increased risk of rectal cancer without a truncating APC mutation (RR intake versus no intake 1.79, 95% CI 1.10-2.90). No associations were observed for meat consumption and tumours lacking hMLH1 expression. Conclusions: Our data indicate that several types of meat may contribute differently to the aetiology of colon and rectal cancer, depending on APC mutation status but not hMLH1 expression of the tumour. © Springer 2005.
Topics
Food and Chemical Risk AnalysisAdenomatous polyposis coliColorectal cancerhMLH1APC proteinProtein MLH1AdultBeef cattleCancer epidemiologyCancer riskColon cancerConfidence intervalControlled studyDisease associationFood intakeGene expressionGene mutationLambMajor clinical studyMeat industryPriority journalRectum cancerAdenomatous Polyposis ColiAdenomatous Polyposis Coli ProteinAgedAnimalsCarrier ProteinsColonic NeoplasmsDietDNA RepairDNA-Binding ProteinsFemaleFishesGene ExpressionGenes, APCHumansMaleMeatMiddle AgedMutationNetherlandsNuclear ProteinsProspective StudiesQuestionnairesRectal Neoplasms
TNO Identifier
238793
ISSN
09575243
Source
Cancer Causes and Control, 16(9), pp. 1041-1054.
Pages
1041-1054
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