Modulation of the cytokine network in human adult astrocytes by human herpesvirus-6A
article
Human herpesvirus-6A (HHV-6A) is a common pathogen whose role in CNS disorders including multiple sclerosis remains controversial. To understand how HHV-6A could influence inflammatory pathways in the CNS, we infected cultured human adult astrocytes and examined the expression of 268 cytokines, chemokines, growth factors and their receptors by gene profiling. HHV-6 infection alone had little effect on the astrocyte gene profile but strongly altered the astrocyte response to proinflammatory cytokines. Under those conditions astrocytes express higher levels of anti-inflammatory mediators including IL-10 and IL-11, chemotactic factors, growth factors and factors controlling type I interferon production. Our data suggest that HHV-6 itself does not evoke a pro-inflammatory response in astrocytes but rather triggers immune modulatory factors in the face of inflammation. © 2005 Elsevier B.V. All rights reserved. Chemicals / CAS: Cytokines; DAPI, 47165-04-8; Glial Fibrillary Acidic Protein; Growth Substances; Indoles; Receptors, Cytokine; Receptors, Growth Factor
Topics
AstrocytesCytokinesGene profilingHHV-6Inflammationchemokinechemotactic factorgrowth factorgrowth factor receptorinterleukin 10interleukin 11agedcontrolled studycytokine productionfemalegene expression profilinghuman cellhuman cell cultureHuman herpesvirus 6human tissueimmune responseimmunomodulationinflammationnucleotide sequencepriority journalprotein expressionunindexed sequencevirus infectionAstrocytesBrainCells, CulturedCytokinesGene Expression ProfilingGene Expression RegulationGlial Fibrillary Acidic ProteinGrowth SubstancesHerpesvirus 6, HumanHumansIndolesModels, BiologicalReceptors, CytokineReceptors, Growth FactorRegression AnalysisT-Lymphocytes
TNO Identifier
238594
ISSN
01655728
Source
Journal of Neuroimmunology, 164(1-2), pp. 37-47.
Pages
37-47
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