Biological evaluation of Tyr6 and Ser7 modified drosocin analogues

article






Visser, P.C. de

Hooft, P.A.V. van

Vries, A.M. de

Jong, A. de

Marel, G.A. van der

Overkleeft, H.S.

Noort, D.
An array of analogues of the cationic antimicrobial peptide drosocin was synthesized containing substitutions of Tyr6 and Ser7 in order to increase the proteolytic stability. Stabilizing the N-terminus with unnatural amino acids increased the serum stability of analogues by almost a factor 30 over an 8 h period. © 2005 Elsevier Ltd. All rights reserved.
Topics























Antibiotic agentAmino acid substitutionAmino terminal sequenceArticleControlled studyDrug screeningDrug stabilityDrug synthesisNonhumanProtein degradationAmino Acid SequenceGlycopeptidesHumansMicrobial Sensitivity TestsMolecular Sequence DataSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationChemicalsDrosocin, 179048-25-0Serine, 56-45-1, 6898-95-9Tyrosine, 16870-43-2, 55520-40-6, 60-18-4Drosocin, 149924-99-2GlycopeptidesSerine, 56-45-1Tyrosine, 55520-40-6
TNO Identifier
238547
Repository link
https://resolver.tno.nl/uuid:bd9b2348-4cfd-4098-9c3c-2c800408f0ce
ISSN
0960-894X
Source
Bioorganic and Medicinal Chemistry Letters, 15(11), pp. 2902-2905.
Pages
2902-2905
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