Meat consumption and K-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study
article
Case-cohort analyses were performed on meat and fish consumption in relation to K-ras mutations in 448 colon and 160 rectal cancers that occurred during 7.3 years of follow-up, excluding the first 2.3 years, and 2948 subcohort members of The Netherlands Cohort Study on diet and cancer. Adjusted incidence rate ratios and 95% confidence intervals were computed for colon and rectal cancer and for K-ras mutation status subgroups. Total fresh meat, most types of fresh meat and fish were not associated with colon or rectal cancer, neither overall nor with K-ras mutation status. However, several weak associations were observed for tumours with a wild-type K-ras, including beef and colon tumours, and an inverse association for pork with colon and rectal tumours; for meat products, an increased association was observed with wild-type K-ras tumours in the colon and possibly with G > A transitions in rectal tumours. © 2005 Cancer Research UK.
Topics
Food and Chemical Risk AnalysisColonMeatRectumWild-type K-rasNitrosaminePolycyclic aromatic hydrocarbonCancer incidenceCancer patientColon cancerDietary intakeFemaleGene mutationGenetic heterogeneityGenetic riskMajor clinical studyRectum cancerWild typeAgedCase-Control StudiesCohort StudiesColonic NeoplasmsDietDNA Mutational AnalysisFemaleGenes, rasHumansMaleMeatMeat ProductsMiddle AgedNetherlandsRectal NeoplasmsRisk FactorsSeafood
TNO Identifier
238433
ISSN
00070920
Source
British Journal of Cancer, 92(7), pp. 1310-1320.
Pages
1310-1320