Mannosylated PLP139-151 induces peptide-specific tolerance to experimental autoimmune encephalomyelitis
article
SJL mice immunized with mannosylated (M-) PLP139-151 in complete adjuvant do not develop EAE and little CNS mononuclear cell infiltration; other mannosylated peptides were ineffective in this experimental setting. Despite apparently normal T cell responses, M-PLP139-151-immunized mice show impaired delayed-type-sensitivity to PLP139-151 but a normal response to other peptides. After re-immunization with PLP139-151 in complete adjuvant, these mice are largely tolerant to EAE, show less T cell proliferation and decreased peptide-specific IgG2a. Our data suggest that M-PLP139-151 induces peptide-specific tolerance to EAE via a mechanism of deletion or impaired migration of encephalitogenic T cells. © 2004 Elsevier B.V. All rights reserved. Chemicals / CAS: Immunodominant Epitopes; Mannose, 31103-86-3; Myelin Proteolipid Protein; Peptide Fragments; proteolipid protein 139-151
Topics
C-type lectinsEAEMannose-receptorToleranceimmunoglobulin G2myelin proteolipid protein[139-151]proteolipid proteinunclassified drugallergic encephalomyelitisanimal cellanimal experimentanimal modelanimal tissuecell migrationcell proliferationcontrolled studydelayed hypersensitivitydrug effectdrug efficacyfemaleimmunizationmousenonhumanpriority journalT lymphocyteAmino Acid SequenceAnimalsCell MovementCells, CulturedCentral Nervous SystemEncephalomyelitis, Autoimmune, ExperimentalFemaleHypersensitivity, DelayedImmunodominant EpitopesInjections, SubcutaneousLeukocytes, MononuclearMannoseMiceMolecular Sequence DataMyelin Proteolipid ProteinPeptide FragmentsSelf ToleranceSeverity of Illness IndexTh1 Cells
TNO Identifier
238383
ISSN
01655728
Source
Journal of Neuroimmunology, 160(1-2), pp. 178-187.
Pages
178-187
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