Relation of height, body mass, energy intake, and physical activity to risk of renal cell carcinoma: Results from the Netherlands Cohort Study
article
Data from the Netherlands Cohort Study on Diet and Cancer were used to investigate the association between anthropometry, energy intake, and physical activity and risk of renal cell carcinoma (RCC). The Netherlands Cohort Study on Diet and Cancer consists of 120,852 men and women aged 55-69 years who completed a self-administered questionnaire at baseline (1986). A case-cohort approach was used. After 9.3 years of follow-up, 275 microscopically confirmed incident cases were available for analysis. Incidence rate ratios for RCC were estimated using Cox proportional hazards models. Height was associated with RCC risk only in women (per 5-cm increment, rate ratio (RR) = 1.23, 95% confidence interval (CI): 1.03, 1.46). Body mass index (weight (kg)/height (m)2) was associated with increased risk of RCC (per 1-kg/m2 increment, RR = 1.07, 95% CI: 1.02, 1.12) for men and women, as was gain in body mass index from age 20 years to baseline (per 1-kg/m2 increment, RR = 1.06, 95% CI: 1.01, 1.10). Energy intake was not related to RCC risk, while a possible protective effect was observed for physical activity in men. These results suggest that body mass index and gain in body mass index since age 20 are associated with increased risk of RCC.
Topics
Food and Chemical Risk AnalysisAnthropometryBody heightBody mass indexCarcinoma, renal cellEnergy intakeExerciseKidney neoplasmsLeisure activitiesBody massCancerEnergy useRecreational activityRisk factorAdultAgedAnthropometryBody fatBody heightBody massCaloric intakeCohort analysisData analysisExerciseFemaleHumanIncidenceKidney carcinomaLeisureLipid peroxidationMajor clinical studyMaleNetherlandsPhysical activityQuestionnaireWeight gainAgedBody HeightBody Mass IndexCarcinoma, Renal CellEnergy IntakeFemaleFollow-Up StudiesHumansKidney NeoplasmsMaleMiddle AgedMotor ActivityNetherlandsProspective StudiesRisk FactorsWeight Gain
TNO Identifier
238254
ISSN
0002-9262
Source
American Journal of Epidemiology, 160(12), pp. 1159-1167.
Pages
1159-1167
Files
To receive the publication files, please send an e-mail request to TNO Repository.