C-reactive protein as a risk factor versus risk marker
article
Purpose of review C-reactive protein (CRP) is consistently associated with cardiovascular disease in prospective and cross-sectional clinical and epidemiological studies. Inflammation is an important mechanism in cardiovascular disease, and the plasma level of CRP is considered to. reflect the inflammatory condition of the patient and/or the vessel wall. In addition, there are also a number of indications for a causal role of CRP in cardiovascular disease. Recent findings A number of new publications show potential causal effects of CRP on cardiovascular disease, and evidence from human-CRP transgenic animals also indicates a causal contribution of CRP to cardiovascular disease. On the other hand, a new large prospective study and an updated meta-analysis indicate that the contribution of CRP to cardiovascular disease is less impressive than reported earlier (odds ratio, 1.58; 95% confidence interval, 1.48-1.68). Summary We review here the most recent evidence on mechanisms by which CRP is involved as a causal factor in the precipitation of cardiovascular disease. Evidence for such a role is accumulating. Chemicals / CAS: C reactive protein, 9007-41-4; Biological Markers; C-Reactive Protein, 9007-41-4
Topics
AtherosclerosisInflammationThrombosisblood levelblood vessel wallcardiovascular riskclinical trialevidence based medicinegeneticsmeta analysisnonhumanpathogenesisreviewsystematic reviewthrombosistransgenic animalBiological MarkersC-Reactive ProteinCardiovascular DiseasesCoronary ArteriosclerosisCoronary DiseaseEndothelial CellsHumansMonocytesRisk FactorsAnimalia
TNO Identifier
238122
ISSN
09579672
Source
Current Opinion in Lipidology, 15(6), pp. 651-657.
Pages
651-657
Files
To receive the publication files, please send an e-mail request to TNO Repository.