De incidentie en de eerste symptomen van diabetes mellitus type 1 bij 0-14-jarigen in Nederland, 1996-1999 [The incidence and initial symptoms of diabetes mellitus type 1 in 0-14-year-olds in the Netherlands, 1996-1999]
article
Objective. To determine the incidence and characteristics of type-1 diabetes mellitus (DM) in children aged 0-14 years during the period 1996-1999 and to compare this with previous measurements of the incidence. Design. Descriptive. Method. Data were collected via reports from all practicing paediatricians to the Dutch Paediatric Surveillance Unit and a questionnaire among members of the Dutch Diabetes Association. The incidence was calculated by the capture-recapture method, and the characteristics and symptoms of the children were determined, from the questionnaires. Results. The incidence of DM type 1 among 0-14-year-olds increased to 18.6/100,000/year (95% CI: 17.7-19.4) compared to 11.1/100,000/year (10.5-11.7) in 1978-1980. The increase was highest in the youngest age group, 0-4 years. DM type 1 was diagnosed at an average age of 7.6 years (7.4-7.9) and in 1988-1990 at 9.2 years (9.0-9.5). The boy-girl ratio also increased. Children with a mother from Surinam, Turkey or the Netherlands Antilles had lower risk of DM type 1 while a higher risk was calculated for children from Moroccan and Somali mothers. In comparison with 1993-1994, there were less frequent lethargy or dehydration; lower average serum-glucose values, a better blood pH and less frequent ketonuria at the time of diagnosis. Treatment on an outpatient basis had increased. However, over the time span 1993-1999, Moroccan children (n = 108) showed dehydration, ketonuria and low blood-pH values more frequently than children of Dutch parents (n = 1825) and their hospital admission lasted longer. Conclusion. The incidence of DM type 1 had increased and the disease manifested itself at a younger age. The clinical condition at time of diagnosis, however, was better. The incidence and clinical characteristics differed between children of different ethnic origin. Chemicals / CAS: glucose, 50-99-7, 84778-64-3
Topics
Age distributionBlood pHCalculationCapture recapture methodDehydrationDemographyDutch Diabetes AssociationDutch Pediatric Surveillance UnitEthnologyGlucose blood levelHospitalizationInsulin dependent diabetes mellitusJuvenile diabetes mellitusKetonuriaLethargyMajor clinical studyMedical societyMotherNational health serviceNewbornRiskSex ratioSymptomatologyTechniqueAdolescentAge FactorsChildChild, PreschoolDiabetes Mellitus, Type 1FemaleHumansIncidenceInfantInfant, NewbornMaleMoroccoNetherlandsNetherlands AntillesQuestionnairesRisk FactorsSex FactorsSomaliaSurinameTurkey
TNO Identifier
237996
ISSN
00282162
Source
Nederlands Tijdschrift voor Geneeskunde, 148(37), pp. 1824-1829.
Pages
1824-1829
Files
To receive the publication files, please send an e-mail request to TNO Repository.