Non-invasive measurement of brain damage in a primate model of multiple sclerosis
article
Early recognition of whether a product has potential as a new therapy for treating multiple sclerosis (MS) relies upon the quality of the animal models used in the preclinical trials. The promising effects of new treatments in rodent models of experimental autoimmune encephalomyelitis (EAE) have rarely been reproduced in patients suffering from MS. EAE in outbred marmoset monkeys, Callithrix jacchus, is a valid new model, and might provide an experimental link between EAE in rodent models and human MS. Using magnetic resonance imaging techniques similar to those used in patients suffering from MS pathological abnormalities in the brain, white matter of the animal can be visualized and quantified. Moreover, NMR spectroscopy, in combination with pattern recognition, offers an advanced uroscopic technique for the identification of biomarkers of inflammatory demyelination.
Topics
Analytical researchMyelinAllergic encephalomyelitisBrain injuryChemometric analysisDemyelinationDiagnostic imagingHumanImmunopathologyMarmosetMultiple sclerosisNeurologic diseaseNeuropathologyNon invasive measurementNonhumanNuclear magnetic resonance imagingNuclear magnetic resonance spectroscopyPattern recognitionPositron emission tomographyProton nuclear magnetic resonanceReviewUrinalysisWhite matterX ray analysisAnimalsAnimals, Outbred StrainsAntigens, CDBiological MarkersBrainCallithrixCD4-Positive T-LymphocytesChronic DiseaseDemyelinating DiseasesDisease Models, AnimalEncephalomyelitis, Autoimmune, ExperimentalGenes, MHC Class IIHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMiceMultiple SclerosisMyelin Basic ProteinsMyelin-Associated GlycoproteinT-Lymphocytes, CytotoxicTh2 CellsAnimaliaCallithrixCallithrix jacchusmarmosetsPrimatesRodentia
TNO Identifier
237600
ISSN
14714914
Source
Trends in Molecular Medicine, 10(2), pp. 85-91.
Pages
85-91
Files
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