Effects of Perinatal Exposure to PCBs on Neuropsychological Functions in the Rotterdam Cohort at 9 Years of Age
article
PCBs are known for their neurotoxic properties, especially on the developing brain. To increase insight into the neurotoxic effects of PCB exposure, the authors studied the effects of perinatal exposure to environmental levels of these compounds on different neuropsychological domains. In 9-year-old children of the Rotterdam PCB-dioxin cohort, higher prenatal PCB levels were associated with longer response times (RTs), more variation in RTs, and lower scores on the Tower of London (TOL; Shallice, 1982). A longer breast-feeding duration was associated with lower TOL scores and with better spatial organizational skills. There was some evidence of negative effects of lactational exposure to PCBs on scores on the TOL.
Topics
Analytical researchPolychlorinated biphenylBreast feedingBreast milkChildCohort analysisComparative studyControlled studyDecision makingDrug effectEnvironmental exposureFemaleHumanInfantIntelligenceLactationLearningMajor clinical studyMaleNetherlandsNeuropsychological testNeuropsychologyNeurotoxicityNonparametric testPollutantPregnancyPrenatal exposurePriority journalPsychomotor performanceReaction timeRegression analysisResponse timeScoring systemShort term memoryVisionBreast FeedingChildCohort StudiesDecision MakingEnvironmental PollutantsFemaleHumansIntelligenceMaleMaternal ExposureMemory, Short-TermMilk, HumanNetherlandsNeuropsychological TestsPolychlorinated BiphenylsPregnancyPrenatal Exposure Delayed EffectsPsychomotor PerformanceReaction TimeRegression AnalysisStatistics, NonparametricVerbal LearningVisual Perception
TNO Identifier
237563
ISSN
08944105
Source
Neuropsychology, 18(1), pp. 185-193.
Pages
185-193
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