Alf QuickZymeT assay for the detection of the anthrax lethal factor activity
conference paper
Anthrax Lethal Factor (ALF) is a Zn2+ dependent metalloprotease that forms an essential part of the deadly anthrax toxin, together with Protective Antigen (PA) and Edema Factor (EF). PA plays a role in the internalisation of both EF and ALF by cells. The internalised ALF specifically cleaves the signal transduction enzymes MAPKKs, ultimately leading to apoptosis, cell death and death of the organism.
ALF is a potential target for drugs to treat patients infected with Bacillus anthracis or patients exposed to the toxin. Assays for the activity of ALF can play a role in early detection of the infection/exposure, to test potentially infected materials or for screening compounds for ALF inhibiting properties.
ALF is a potential target for drugs to treat patients infected with Bacillus anthracis or patients exposed to the toxin. Assays for the activity of ALF can play a role in early detection of the infection/exposure, to test potentially infected materials or for screening compounds for ALF inhibiting properties.
TNO Identifier
183658
Source title
Bacillus-ACT 2005 Conference, Santa Fe, NM, USA, 24-28 September 2005
Pages
Poster
Files
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