Efficacy of pretreatment and treatment against soman intoxication
conference paper
The efficacy against lethality and post-intoxication incapacitation after 2x LD50 soman of different subacute pretreatment scenarios of 12 days was tested with or without post-intoxication therapy in guinea pigs. These pretreatment regimes were 1) the currently used pyridostigmine (PYR, 0.04 mg/kg/hr), 2) the combination of physostigmine (PHY, 0.025 mg/kg/hr) with the muscarinic receptor antagonist scopolamine (SCO, 0.018 mg/kg/hr), and 3) the combination of PHY with the anti-Parkinson drug procyclidine (PC, 3 mg/kg, sc). The post-intoxication therapy consisted of HI-6 (21.4 mg/kg, im), atropine sulphate (AS, 0.085 mg/kg, im), and diazepam (DZP, 0.21 mg/kg, im). Behavioral and observational read-out systems were used to elucidate theseverity of soman induced incapacitation. © 2006 Springer.
Topics
TNO Identifier
183423
ISSN
1871-4641
ISBN
1402041683
9781402041686
9781402041686
Publisher
Springer
Source title
Medical treatment of intoxications and decontamination of chemical agents in the area of terrorist attack. Proceedings of the NATO Advanced Research Workshop, Dnepropetrovsk, Ukraine, 25-28 January 2005
Editor(s)
Dishovsky, C.
Pivovarov, A.
Benschop, H.P.
Pivovarov, A.
Benschop, H.P.
Place of publication
Dordrecht
Pages
113-121 (Chapter 13)
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