Innate, adaptive and regulatory responses in schistosomiasis: Relationship to allergy
article
Helminth infections have profound effects on the immune system. Here, recent insights in the molecular interactions between schistosomes and the host are described with respect to adaptive but also with respect to innate immune responses. Furthermore, the different mechanisms of immune hyporesponsiveness are depicted with emphasis on regulatory T cells. Finally, the relationship between downregulatory responses and allergy is discussed. Copyright © 2006 S. Karger AG.
Topics
Anthelmintic agentImmunoglobulin G4Intercellular adhesion molecule 3Interleukin 13 receptorPattern recognition receptorSTAT1 proteinTetanus toxoidToll like receptor 1Toll like receptor 3Toll like receptor 5Toll like receptor 6Toll like receptor 7Toll like receptor 8AllergyAntibody productionAntigen specificityAtopyBrugia malayiCD4+ CD25+ T lymphocyteCellular immunityChronic diseaseClonal anergyCross toleranceDendritic cellDown regulationEndemic diseaseHelicobacter pyloriHelminthiasisHumanImmune deficiencyImmune responseImmunoregulationInflammationInnate immunityLymphocyte proliferationMast cell degranulationMolecular interactionNippostrongylus brasiliensisNonhumanRegulatory T lymphocyteReviewSchistosomaSchistosoma hematobiumSchistosoma mansoniSchistosomiasisSensitizationT lymphocyte activationT lymphocyte subpopulationTetanusTh1 cellTh2 cellUpregulationAnimalsChronic DiseaseHypersensitivityImmune ToleranceImmunity, NaturalInterleukin 13, 148157-34-0Tetanus toxoid, 57425-69-1, 93384-51-1Toll like receptor 2, 203811-81-8Toll like receptor 4, 203811-83-0Toll like receptor 9, 352486-49-8, 390883-32-6Toll like receptor, 409141-78-2
TNO Identifier
183153
ISSN
1660-2242
Source
Chemical Immunology and Allergy, 90, pp. 157-175.
Pages
157-175
Files
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