Allele-specific expression of the IL-1 gene in human CD4 + T cell clones

Bayley, J.P.; Rietschoten, J.G.I. van; Bakker, A.M.; Baarsen, L. van; Kaijzel, E.L.; Wierenga, E.A.; Kraan, T.C.T.M. van der pouw; Huizinga, T.W.J.; Verweij, C.L.

Allele-specific expression of the IL-1 gene in human CD4 + T cell clones

article

2003

Bayley, J.P.

Rietschoten, J.G.I. van

Bakker, A.M.

Baarsen, L. van

Kaijzel, E.L.

Wierenga, E.A.

Kraan, T.C.T.M. van der pouw

Huizinga, T.W.J.

Verweij, C.L.

A number of reports have described the monoallelic expression of murine cytokine genes. Here we describe the monoallelic expression of the human IL-1? gene in CD4+ T cells. Analysis of peripheral blood T cell clones derived from healthy individuals revealed that the IL-1? gene shows predominantly monoallelic expression. Monoallelic expression was observed in Th0, Th1, and Th2 cell clones. In addition, we demonstrate monoallelic expression in T cell clones from rheumatoid arthritis patients derived from synovial fluid of the knee joint, suggesting that the occurrence of this phenomenon is not different from that in clones derived from healthy individuals. The finding of monoallelic expression of a cytokine gene in human CD4+ T cell clones provides evidence for allele-specific silencing/activation as another layer of regulation of IL-1? gene expression.

Topics

interleukin 1alpha allele article cell clone controlled study gene control gene expression human human cell rheumatoid arthritis synovial fluid T lymphocyte Th1 cell Th2 cell

TNO Identifier

953665

Repository link

https://resolver.tno.nl/uuid:8a2af3bb-915b-4cd7-8b0e-a25e90ff38ed

ISSN

00221767

Source

Journal of Immunology, 171(5), pp. 2349-2353.

Pages

2349-2353

Files

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Allele-specific expression of the IL-1 gene in human CD4 + T cell clones

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