HRT effects on inflammatory markers Is chronic inflammation a contra-indication for HRT
article
Oestrogens have been reported to have effects on inflammatory markers in healthy individuals and patients. Published data on increases in the acute phase marker CRP (C-reactive protein) and decreases in soluble vascular adhesion molecules are summarised here. The original data on the effects of a 6-week treatment with 17-β-oestradiol in post-menopausal type II diabetic women are given for CRP and haemostatic factors. The largest increase in CRP is observed in the highest pre-treatment tertile of CRP. This group is also characterised by high levels of haemostatic risk predictors. It is concluded that some pro- and anti-inflammatory effects of oestrogens appear to exist and that the net effect may be different depending upon location or tissue and individual make-up. It is suggested that women with high levels of habitual CRP may represent a group with chronic inflammation with an unfavourable condition and reaction to oestrogen, thus representing a sub-group with a contra-indication for HRT. © 2002, Elsevier Science B.V. All rights reserved.
TNO Identifier
953606
ISSN
05315131
Source
International Congress Series, 1229(C), pp. 103-108.
Pages
103-108
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