Stereoisomers of soman : Inhibition of serum carboxylic ester hydrolase and potentiation of their toxicity by CBDP (2-(2-methylphenoxy)-4H-1,3,2-benzodioxaphosphorin-2-oxide) in mice - Short communications
article
The interaction of C(±)P(±)-soman (pinacolyl methylphosphonofluoridate) and its individual stereoisomers with serum carboxylic-ester hydrolase and potentiation of their toxicity by a carboxylic-ester hydrolase inhibitor CBDP (2-(2-methylphenoxy)-4H-1,3,2-benzodioxaphosphorin-2-oxide) was investigated. C(±)P(±)-Soman and the individual stereoisomers all inhibited purified mouse serum carboxylic-ester hydrolase to different degrees. C(±)P(±)-Soman and the C(−)P(−)- and C(+)P(−)-isomers had Ki values of 30.6, 18.7, and 35.7 nm, respectively, and C(−)P(+)- and C(+)P(+)-isomers had Ki values of 1412 and 2523 nm, respectively. In toxicity experiments CBDP (0.5 mg/kg; iv 1 hr prior to soman) pretreatment potentiated the toxicity of C(±)P(±)-, C(+)P(−)-, and C(−)P(−)-soman to a similar degree. Thus, it appears that the toxic stereoisomers of soman have a similar affinity for mouse serum carboxylic-ester hydrolase, and CBDP pretreatment does not enhance selectively the toxicity of one stereoisomer over the other.
TNO Identifier
114921
Source
Toxicology and Applied Pharmacology, 89(1), pp. 141-143.
Place of publication
Ral
Pages
141-143
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