The early postnatal development of salivary antibody and immunoglobulin response in children orally colonized with a nonpathogenic, probiotic strain of E. coli
article
The development of levels of secretory immunoglobulins (SIgs) in newborns' saliva was examined under physiological conditions and after artificial colonization with nonpathogenic, probiotic bacterial strain E. coli O83. Higher levels of secretory immunoglobulin M (SIgM) and secretory immunoglobulin A (SIgA) were detected in the saliva of breast-fed children when compared with those of bottle-fed infants. SIgM was found earlier than SIgA, the levels of both SIgM and SIgA decreased after weaning. Breastfeeding actively stimulates local immunity on mucosal membranes of newborn infants. Early mucosal colonization with nonpathogenic E. coli bacteria stimulates the mucosal immune system to produce specific antibodies as well as nonspecific secretory immunoglobulins.
Topics
Bacteria (microorganisms)AntibodyImmunoglobulinProbiotic agentSecretory immunoglobulinBottle feedingBreast feedingEscherichia coliFemaleGrowth, development and agingHumanImmunologyInfantMaleNewbornSalivaImmunoglobulin A, SecretoryInfantInfant, newbornProbioticsImmunoglobulin, 9007-83-4Immunoglobulin A, Secretory
TNO Identifier
237276
ISSN
00155632
Source
Folia Microbiologica, 48(2), pp. 281-287.
Pages
281-287
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