Two-locus linkage analysis applied to putative quantitative trait loci for lipoprotein(a) levels

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Beekman, M.

Heijmans, B.T.

Martin, N.G.

Whitfield, J.B.

Pedersen, N.L.

Faire, U. de

Snieder, H.

Lakenberg, N.

Knijff, P. de

Frants, R.R.

Ommen, G.J.B. van

Kluft, C.

Vogler, G.P.

Slagboom, P.E.

Boomsma, D.I.
Plasma levels of lipoprotein(a) - Lp(a) - are associated with cardiovascular risk (Danesh et al., 2000) and were long believed to be influenced by the LPA locus on chromosome 6q27 only. However, a recent report of Broeckel et al. (2002) suggested the presence of a second quantitative trait locus on chromosome 1 influencing Lp(a) levels. Using a two-locus model, we found no evidence for an additional Lp(a) locus on chromosome 1 in a linkage study among 483 dizygotic twin pairs. Chemicals/CAS: Lipoproteins
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Lipoprotein AAdultCardiovascular diseaseChromosome 1Chromosome 6Dizygotic twinsGenetic linkageHealth statusHeritabilityLipoprotein blood levelMajor clinical studyMonozygotic twinsAdolescentChromosomes, Human, Pair 1Chromosomes, Human, Pair 6HumansLinkage (Genetics)LipoproteinsQuantitative Trait LociTwinsTwins, DizygoticTwins, Monozygotic
TNO Identifier
237208
Repository link
https://resolver.tno.nl/uuid:2cb52ee8-99b7-47de-9594-570027e8aae0
ISSN
13690523
Source
Twin Research, 6(4), pp. 322-324.
Pages
322-324
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