Is Candida albicans a trigger in the onset of coeliac disease?
article
Coeliac disease is a T-cell-mediated autoimmune disease of the small intestine that is induced by ingestion of gluten proteins from wheat, barley, or rye. We postulate that Candida albicans is a trigger in the onset of coeliac disease. The virulence factor of C albicans - hyphal wall protein 1 (HWP1) - contains aminoacid sequences that are identical or highly homologous to known coeliac disease-related α-gliadin and γ-gliadin T-cell epitopes. HWP1 is a transglutaminase substrate, and is used by C albicans to adhere to the intestinal epithelium. Furthermore, tissue transglutaminase and endomysium components could become covalently linked to the yeast. Subsequently, C albicans might function as an adjuvant that stimulates antibody formation against HWP1 and gluten, and formation of autoreactive antibodies against tissue transglutaminase and endomysium.
Topics
Food technologyAutoantibodyBlood clotting factor 13aEpitopeGliadinGlutenHyphal wall protein 1Protein glutamine gamma glutamyltransferaseUnclassified drugVirulence factorAmino acid sequenceAntibody productionAutoimmune diseaseCandida albicansCandidiasisCeliac diseaseCovalent bondEnzyme activityGenetic predispositionHumanImmunoreactivityIntestine epitheliumIntestine floraNonhumanPathophysiologyPriority journalProtein expressionSequence analysisSequence homologyAntibody FormationCandida albicansCeliac DiseaseFungal ProteinsGenetic Predisposition to DiseaseGliadinHumansIntestinal MucosaMembrane GlycoproteinsTransglutaminasesVirulence
TNO Identifier
237150
DOI
https://dx.doi.org/10.1016/S0140-6736(03)13695-1
ISSN
01406736
Source
Lancet, 361(9375), pp. 2152-2154.
Pages
2152-2154
Files
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