Investigating the role of natural phyto-oestrogens on bone health in postmenopausal women
article
Research on the bone effects of natural phyto-oestrogens after menopause is at a relatively early stage. Published studies are few, difficult to compare and often inconclusive, due in part to design weaknesses. Currently, many questions remain to be answered including to what extent a safe daily intake may prevent postmenopausal bone loss. These questions can only be addressed by conducting well-planned, randomised clinical trials that take into consideration present knowledge in the oestrogen, phyto-oestrogen and bone fields. This review is intended to provide hints for critical decision-making about the selection of subjects, type of intervention, suitable outcome measures and variables that need to be controlled.
Topics
Physiological SciencesClinical trialsIsoflavonesMenopauseAcid phosphatase tartrate resistant isoenzymeAlkaline phosphatase bone isoenzymeBiochemical markerCollagen aminopeptideCollagen c peptideCollagen derivativeDeoxypyridinolineIsoflavoneOsteocalcinPhytoestrogenProcollagen c propeptideProcollagen n propeptidePyridinolineSialoproteinSoybean proteinUnclassified drugEstrogenIsoflavone derivativePlant medicinal productBone densityBone metabolismBone mineralBone remodelingBone strengthBone turnoverClinical trialDiet supplementationDiet therapyDietary intakeEvidence based medicineGenetic variabilityHumanMedical decision makingMenopausal syndromeNonhumanOssificationOsteoporosisOutcomes researchPatient compliancePatient monitoringPatient selectionPhysical activityPostmenopauseReviewShort course therapyChemistryControlled clinical trialDietFemaleMethodologyMiddle agedPostmenopause osteoporosisRandomized controlled trialSoybeanTreatment outcomeGlycine maxDietEstrogens, Non-SteroidalFemaleHumansIsoflavonesMiddle AgedOsteoporosis, PostmenopausalPhytoestrogensPlant PreparationsRandomized Controlled TrialsResearch DesignSoybeansTreatment Outcome
TNO Identifier
237117
ISSN
00071145
Source
British Journal of Nutrition, 89(SUPPL. 1)