Elevated osteopontin levels in active relapsing-remitting multiple sclerosis

article




Vogt, M.H.J.

Lopatinskaya, L.

Smits, M.

Polman, C.H.

Nagelkerken, L.
In the search for proteins that might play a role in the pathogenesis of multiple sclerosis (MS), osteopontin (OPN) has been identified as the most prominent cytokine-encoding gene expressed within MS lesions. Here, we report significantly increased OPN protein levels in plasma of relapsing-remitting MS patients. In contrast, OPN protein levels in primary progressive and secondary progressive MS patients were similar to healthy control levels. Interestingly, active relapsing-remitting patients had higher OPN protein levels than patients without relapses. Chemicals/CAS: interferon beta serine, 90598-63-3; osteopontin, 106441-73-0; Osteopontin, 106441-73-0; Sialoglycoproteins; SPP1 protein, human
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plasma proteinadultclinical articlecontrolled studydisease activitydisease coursedisease exacerbationdrug effectfollow upgene expressiongenetic codepathogenesisrelapseupregulationEnzyme-Linked Immunosorbent AssayFemaleHumansMaleMiddle AgedMultiple Sclerosis, Chronic ProgressiveMultiple Sclerosis, Relapsing-RemittingOsteopontinSialoglycoproteins
TNO Identifier
237110
Repository link
https://resolver.tno.nl/uuid:4067e416-56eb-4c02-92ef-2bf9e763cdb9
ISSN
03645134
Source
Annals of Neurology, 53(6), pp. 819-822.
Pages
819-822
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