Collagenases (MMP-1, -8 and -13) and trypsinogen-2 in fluid from benign and malignant ovarian cysts

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Stenman, M.

Paju, A.

Hanemaaijer, R.

Tervahartiala, T.

Leminen, A.

Stenman, U.H.

Konttinen, Y.T.

Sorsa, T.
Proteolytic enzymes, such as matrix metalloproteinases (MMPs) and tumor-associated trypsinogens (TAT), play a pivotal role in tumor invasion and metastasis. Among MMPs, the interstitial collagenases (MMP-1, -8 and -13) can initiate collagenolysis. In this study, we have studied the levels of MMP-1, -8 and -13 in relation to the level of trypsinogen-2 in fluid from benign and malignant ovarian cysts. Elevated MMP-8 levels occur in many ovarian cyst fluids, and high MMP-8 levels are associated with malignancy. The concentrations of trypsinogen-2 correlate with those of MMP-8, but it remains to be shown whether trypsin-2 plays a role as its activator in vivo. The strong expression of MMP-8 over MMP-1 and MMP-13 in malignant ovarian tumors may indicate that MMP-8 participates in the protease cascades associated with the invasiveness of ovarian tumors. Copyright © 2003 S. Karger AG, Basel. Chemicals/CAS: collagenase 3, 175449-82-8; interstitial collagenase, 9001-12-1; trypsinogen, 9002-08-8; Collagenases, EC 3.4.24.-; Matrix Metalloproteinase 1, EC 3.4.24.7; Matrix Metalloproteinase 13, EC 3.4.24.-; Matrix Metalloproteinase 8, EC 3.4.24.34; MMP13 protein, human, EC 3.4.24.-; PRSS2 protein, human, 103964-84-7; Trypsin, EC 3.4.21.4; Trypsinogen, 9002-08-8
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CollagenaseCyst fluidMetalloproteinasesMMP-1MMP-8Ovarian cystTrypsinWMMP-13collagenase 3interstitial collagenaseneutrophil collagenasetrypsinogenadolescentadultagedarticleconcentration responsecontrolled studycyst fluiddisease associationfemalehumanhuman cellin vivo studyliquidovary carcinomaovary cystpriority journalprotein blood levelprotein expressionAdolescentAdultAgedCollagenasesFemaleHumansMatrix Metalloproteinase 1Matrix Metalloproteinase 13Matrix Metalloproteinase 8Middle AgedOvarian CystsTrypsinTrypsinogen
TNO Identifier
237092
Repository link
https://resolver.tno.nl/uuid:409fc59c-80ce-435d-8291-3697f69bf0ce
ISSN
10104283
Source
Tumor Biology, 24(1), pp. 9-12.
Pages
9-12
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