Immunomodulatory effects of orally administered cannabinoids in multiple sclerosis

article







Killestein, J.

Hoogervorst, E.L.J.

Reif, M.

Blauw, B.

Smits, M.

Uitdehaag, B.M.J.

Nagelkerken, L.

Polman, C.H.
Cannabinoids can modulate the function of immune cells. We here present the first human in vivo study measuring immune function in 16 MS patients treated with oral cannabinoids. A modest increase of TNF-α in LPS-stimulated whole blood was found during cannabis plant-extract treatment (p=0.037), with no change in other cytokines. In the subgroup of patients with high adverse event scores, we found an increase in plasma IL-12p40 (p=0.002). The results suggest pro-inflammatory disease-modifying potential of cannabinoids in MS. © 2003 Elsevier Science B.V. All rights reserved. Chemicals/CAS: cannabis, 8001-45-4, 8063-14-7; dronabinol, 7663-50-5; Adjuvants, Immunologic; Cannabinoids; Plant Extracts; Tetrahydrocannabinol, 1972-08-3
Topics
































CytokinesTHCDronabinolLipopolysaccharideTumor necrosis factor alphaAtaxiaClinical articleControlled studyDrug effectHeadacheImmune function testImmunomodulationIn vivo studyMental instabilitySomnolenceSpasticityVertigoXerostomiaAdjuvants, ImmunologicAdministration, OralAdultCannabinoidsCannabisConfidence IntervalsCross-Over StudiesFemaleHumansMaleMiddle AgedMultiple SclerosisPhytotherapyPlant ExtractsTetrahydrocannabinol
TNO Identifier
237029
Repository link
https://resolver.tno.nl/uuid:605056bb-49fe-4ce5-b080-29efd59517e7
ISSN
01655728
Source
Journal of Neuroimmunology, 137(1-2), pp. 140-143.
Pages
140-143
Files
To receive the publication files, please send an e-mail request to TNO Repository.