Height, weight, weight change, and ovarian cancer risk in the Netherlands Cohort Study on Diet and Cancer
article
Although many studies have been conducted to investigate the relation between anthropometry and the risk of ovarian cancer, their results have been inconsistent. The Netherlands Cohort Study on Diet and Cancer was initiated in 1986. A self-administered questionnaire on dietary habits and other risk factors for cancer was completed by 62,573 women. Follow-up for cancer was implemented by annual record linkages with the Netherlands Cancer Registry. After 7.3 years of follow-up, 172 incident cases of invasive epithelial ovarian cancer were available for analysis. Multivariate analysis yielded a rate ratio of ovarian cancer for women with adult height of more than 175 cm, compared with those with height of less than or equal to 160 cm, of 2.17 (95% confidence interval: 1.14, 4.13; p trend = 0.01). The rate ratio for women with a body mass index of more than 30 kg/m2 was 1.69 (95% confidence interval: 1.00, 2.86), compared with women with a Quetelet index of less than 25 kg/m2, with p trend = 0.06. Rate ratios for weight and body mass index at age 20 years were nonsignificantly increased in the intermediate categories. These data support a positive association between height (and to a lesser extent body mass) and ovarian cancer risk in this population of postmenopausal women.
Topics
Food and Chemical Risk AnalysisBody constitutionBody heightBody mass indexBody weightCohort studiesOvarian neoplasmsCancerAdultAnthropometryBody heightBody massBody weightCancer registryCancer riskCohort analysisDietary intakeFemaleHumanMajor clinical studyNetherlandsObesityOvary cancerPostmenopauseQuestionnaireAgedAged, 80 and overBody ConstitutionBody HeightBody Mass IndexBody WeightConfounding Factors (Epidemiology)Diet SurveysFemaleHumansIncidenceLikelihood FunctionsMiddle AgedNetherlandsOvarian NeoplasmsPostmenopauseProspective StudiesQuestionnairesRegistriesRegression AnalysisRisk Factors
TNO Identifier
236979
ISSN
0002-9262
Source
American Journal of Epidemiology, 157(5), pp. 424-433.
Pages
424-433
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