The production of antibody fragments and antibody fusion proteins by yeasts and filamentous fungi

article



Joosten, V.

Lokman, C.

Hondel, C.A.M.J.J. van den

Punt, P.J.
In this review we will focus on the current status and views concerning the production of antibody fragments and antibody fusion proteins by yeasts and filamentous fungi. We will focus on single-chain antibody fragment production (scFv and VHH) by these lower eukaryotes and the possible applications of these proteins. Also the coupling of fragments to relevant enzymes or other components will be discussed. As an example of the fusion protein strategy, the 'magic bullet' approach for industrial applications, will be highlighted. © 2003 Joosten et al; licensee BioMed Central Ltd.
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BiotechnologyCancer antibodyCell antibodyFungus antibodyHybrid proteinImmunoglobulinImmunoglobulin F(ab) fragmentImmunoglobulin Fc fragmentImmunoglobulin heavy chainImmunoglobulin light chainIntrabodyRecombinant antibodySingle chain fragment variable antibodyUnclassified drugAntibody combining siteAntibody productionAntigen bindingAspergillus awamoriCandida boidiniiClinical trialDrug clearanceDrug delivery systemEscherichia coliEukaryoteGene expression systemHansenula polymorphaHumanImmunotherapyKluyveromycesMethylotrophic bacteriumMycologyNonhumanPichiaPichia methanolicaPichia pastorisProtein protein interactionProtein synthesisReviewSaccharomyces cerevisiaeSchizosaccharomyces pombeTrichoderma reeseiYarrowia lipolyticaEukaryotaFungi
TNO Identifier
236944
Repository link
https://resolver.tno.nl/uuid:47de520f-fb56-4432-a4b1-4f891e52dfd8
ISSN
14752859
Source
Microbial Cell Factories, 2
Article nr.
No.: 1
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