Lactobacilli as live vaccine delivery vectors: Progress and prospects

article
Seegers, J.F.M.L.
Evidence is accumulating that lactobacilli influence the immune response in a strain-dependent manner. This immunomodulatory capacity is important for the development of the immune response, and also identifies Lactobacillus as a potent oral vaccine carrier. Most of our current knowledge of the use of lactobacilli for vaccination purposes has been obtained with tetanus toxin fragment C (TTFC) as the model antigen. This knowledge, together with our ever-increasing understanding of the immune system and recent developments in cloning and expression techniques, should enable the utilisation of antigens other than TTFC and has made the development of lactobacilli as live vaccines a realistic prospect. Chemicals/CAS: Bacterial Vaccines; Peptide Fragments; Recombinant Proteins; tetanus toxin fragment C; Tetanus Toxin; Vaccines, Synthetic
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AntigensCloningImmunologyBiotechnologyCytokineDrug carrierImmunoglobulin AImmunoglobulin GImmunoglobulin MInfluenza vaccineLive vaccineNeutralizing antibodyCytokine productionDrug delivery systemDrug effectGene expressionImmune responseImmunomodulationLactic acid bacteriumMolecular cloningBacterial VaccinesCloning, MolecularDrug Delivery SystemsGastrointestinal DiseasesHumansLactobacillusPeptide FragmentsProbioticsRecombinant ProteinsSpecies SpecificityTetanus ToxinVaccinationVaccines, SyntheticBacteria (microorganisms)LactobacillusNegibacteria
TNO Identifier
236824
Repository link
https://resolver.tno.nl/uuid:c31c2c36-0844-4cb0-8127-2b34f5db5d30
ISSN
01677799
Source
Trends in Biotechnology, 20(12), pp. 508-515.
Pages
508-515
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