Molecular markers for osteoarthritis: The road ahead
article
Osteoarthritis is a disabling joint disease that is characterized by the progressive destruction of articular cartilage. Diagnosis is based on clinical symptoms in combination with radiography, which is relatively insensitive and provides only an indication of accumulated damage. Alternative methods, such as molecular markers, are therefore needed that can quantitatively, reliably, and sensitively detect osteoarthritic changes in the joints at an early stage of the disease. Such molecular markers are essential for diagnosis, prognosis, and monitoring of disease progression and efficacy of therapy that is targeted at joint destruction. In addition, these markers are important for the development of new disease-modifying therapies. This concise review discusses the developments over the past 2 years in the field of molecular markers for osteoarthritis. © 2002 Lippincott Williams & Wilkins, Inc. Chemicals/CAS: cartilage oligomeric matrix protein, 161028-53-1; chondroitin sulfate, 9007-28-7, 9082-07-9; collagen, 9007-34-5; hyaluronic acid, 31799-91-4, 9004-61-9, 9067-32-7; keratan sulfate, 69992-87-6, 9056-36-4; osteocalcin, 136461-80-8; tissue inhibitor of metalloproteinase, 97837-28-0; Matrix Metalloproteinases, EC 3.4.24.-; Collagen Type II; Cross-Linking Reagents; Genetic Markers; Proteoglycans
Topics
Biomedical Researchbiological markercartilage oligomeric matrix proteinchondroitin sulfatecollagencollagen type 2cytokineepitopehyaluronic acidkeratan sulfatematrix metalloproteinaseosteocalcinproteoglycansialoproteintissue inhibitor of metalloproteinasetransforming growth factor beta1tumor necrosis factor receptor 2cross linking reagentarthritisarticular cartilagecollagen synthesiscross linkingdisease courseinflammationprognosisreviewsynoviumextracellular matrixgenetic markergeneticsmetabolismpathologyCollagen Type IICross-Linking ReagentsExtracellular MatrixGenetic MarkersMatrix MetalloproteinasesOsteoarthritisProteoglycansSupport, Non-U.S. Gov'tHumans
TNO Identifier
236670
ISSN
10408711
Source
Current Opinion in Rheumatology, 14(5), pp. 585-589.
Pages
585-589
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