Development of biochemical heterogeneity of articular cartilage: Influences of age and exercise
article
The objective of this study was to document the development of biochemical heterogeneity from birth to maturity in equine articular cartilage, and to test the hypothesis that the amount of exercise during early life may influence this process. Neonatal foals showed no biochemical heterogeneity whatsoever, in contrast to a clear biochemical heterogeneity in mature horses. The process of formation of site differences was almost completed in exercised foals age 5 months, but was delayed in those deprived of exercise. For some collagen-related parameters, this delay was not compensated for after an additional 6 month period of moderate exercise. It is concluded that the functional adaptation of articular cartilage, as reflected in the formation of biochemical heterogeneity in the horse, occurs for the most part during the first 5 months postpartum. A certain level of exercise seems essential for this process and withholding exercise in early life, may result in a delay in the adaptation of the cartilage.
Topics
Biomedical ResearchAgeBiochemical heterogeneityCartilageDevelopmentExerciseHorseCollagenDNAGlycosaminoglycanHydroxylysineHydroxyprolineAdaptationAnimal experimentArticular cartilageBiochemistryCell heterogeneityControlled studyExerciseHorseNonhumanPuerperiumAgeAgingAnimalAnimal diseaseChemistryHigh performance liquid chromatographyJointMethodologyNewbornPhysiologyAnimaliaEquidaeEquus caballusAdaptation, PhysiologicalAge FactorsAgingAnimalsAnimals, NewbornCartilage, ArticularChromatography, High Pressure LiquidCollagenDNAGlycosaminoglycansHorsesHydroxylysineHydroxyprolineJointsPhysical Conditioning, Animal
TNO Identifier
236539
ISSN
04251644
Source
Equine Veterinary Journal, 34(3), pp. 265-269.
Pages
265-269
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