Altered glucocorticoid regulation of the immune response in the chronic fatigue syndrome

article


Visser, J.T.J.

Kloet, E.de

Nagelkerken, L.
It is increasingly recognized that glucocortiocoids (GCs) can have subtle modulatory effects in immunoregulation rather than having generalized immunosuppressive effects. GCs suppress Th1 cells and cellular immunity, but may favor Th2 responses and humoral immunity. The chronic fatigue syndrome (CFS) appears to be associated with a disturbed HPA-axis. Moreover, CFS patients show several immunological changes suggestive of decreased cellular immunity. It is postulated herein that in CFS patients a decreased Th1/Th2 balance may be the result of selective effects of GC on the IL-10/IL-12 regulatory circuit. Chemicals/CAS: Glucocorticoids
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Interleukin 10Interleukin 12Autoimmune diseaseCellular immunityChronic fatigue syndromeConference paperHumoral immunityHypothalamus hypophysis adrenal systemImmune responseImmunomodulationNeuroendocrinologyTh1 cellTh2 cellFatigue Syndrome, ChronicGlucocorticoidsHumansImmunityNeuroimmunomodulation
TNO Identifier
235899
Repository link
https://resolver.tno.nl/uuid:559d151b-98e0-4e11-a201-1639dfc5a607
ISSN
00778923
Source
Annals of the New York Academy of Sciences, 917, pp. 868-875.
Pages
868-875
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