Association between trans fatty acid intake and cardiovascular risk factors in Europe: The TRANSFAIR study
article
Background: High intakes of trans fatty acids (TFA) have been found to exert an undersirable effect on serum lipid profiles, and thus may increase the risk for cardiovascular disease. Objective: Investigation of the association between TFA intake and serum lipids. Design: Cross-sectional study in eight European countries (Finland, France, Greece, Iceland, The Netherlands, Portugal, Spain, Sweden) among 327 men and 299 women (50-65 y). Using a dietary history method, food consumption was assessed and TFA intake was calculated with recent figures on TFA levels of foods, collected in the TRANSFAIR study. Results: Mean (±s.d.) TFA intake was 2.40 ± 1.53 g/day for men and 1.98±1.49 g/day for women (0.87±0.48% and 0.95±0.55% of energy, respectively), with the highest consumption in Iceland and the lowest in the Mediterranean countries. No associations were found between total TFA intake and LDL, HDL or LDL/HDL ratio after adjustment for cardiovascular risk factors. Additional adjustment for other fatty acid clusters resulted in a significant inverse trend between total TFA intake and total cholesterol (P(trend)<0.03). The most abundantly occuring TFA isomer, C18:1 t, contributed substantially to this inverse association. The TFA isomers C14:1 t9, C16:1 t9 and C22:1 t were not associated or were positively associated with LDL or total cholesterol. Conclusions: From this study we conclude that at the current European intake levels of trans fatty acids they are not associated with an unfavourable serum lipid profile.
Topics
Fatty acidHigh density lipoproteinLow density lipoproteinAdultAgedCardiovascular diseaseCholesterol blood levelControlled studyDisease associationEuropeFat intakeFemaleFood intakeHumanLipid blood levelLipid compositionMajor clinical studyMaleRisk factorTrans isomerAdipose TissueAgedCardiovascular DiseasesCholesterolCross-Sectional StudiesDiet RecordsDietary FatsEnergy IntakeEuropeFatty AcidsFemaleHumansIsomerismLinear ModelsLipidsLipoproteins, HDLLipoproteins, LDLMaleMiddle AgedRisk Factors
TNO Identifier
235517
ISSN
09543007
Source
European Journal of Clinical Nutrition, 54(2), pp. 126-135.
Pages
126-135
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